PUBLICATIONS

68 publications found

2025

• Prevent and Reverse Metabolic Dysfunction-Associated Steatohepatitis and Hepatic Fibrosis via mRNA-Mediated Liver-Specific Antibody Therapy
  Chenshuang Zhang, Yilong Teng, Xin Bai, Maoping Tang, William Stewart, Jake Jinkun Chen, Xiaoyang Xu, and Xue-Qing Zhang, ACS Nano
• Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA
  Hu, B., Stewart, W., Chen, Q. et al, Nat Commun 16
• Budesonide-incorporated inhalable lipid nanoparticles for antiTSLP nanobody mRNA delivery to treat steroid-resistant asthma
  Huang, J., Bai, X., Stewart, W. et al, Nat Commun 16
• Computationally Aided Design of Ionizable Cholesteryl Lipids for Lipid Nanoparticles to Modulate Hepatic mRNA Accumulation
  Yilong Teng, Yuxuan Guo, Zhixiang Liu, Maoping Tang, William Stewart, Xiaoyang Xu*, Xue-Qing Zhang*, J. Am. Chem. Soc
• A combinatorial siRNA and mRNA approach for obesity treatment using targeting lipid nanoparticles
  William Stewart, Bin Hu, Fengqiao Li, Jia Huang, Zhixiang Liu, Chenshuang Zhang, Maoping Tang, Xue-Qing Zhang, Xiaoyang Xu, Journal of Controlled Release
• 33 Unresolved Questions in Nanoscience and Nanotechnology
  Chad Mirkin* et, al, ACS. Nano

2024

• Targeted mRNA Nanoparticles Ameliorate Blood–Brain Barrier Disruption Postischemic Stroke by Modulating Microglia Polarization
  Mingzhu Gao, Yan Li, William Ho, Chen Chen, Qijing Chen, Fengshi Li, Maoping Tang, Qiuyue Fan, Jieqing Wan, Weifeng Yu, Xiaoyang Xu, Peiying Li, and Xue-Qing Zhang, ACS Nano
• Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy
  Xin Bai, Qijing Chen, Fengqiao Li, Yilong Teng, Maoping Tang, Jia Huang, Xiaoyang Xu, Xue-Qing Zhang, Nature Communication 15
• Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis
  Mingzhu Gao, Maoping Tang, William Ho, Yilong Teng, Qijing Chen, Lei Bu, Xiaoyang Xu, Xue-Qing Zhang, ACS Nano
• Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion
  Bin Wang, Maoping Tang, Qijing Chen, William Ho, Yilong Teng, Xiaojian Xiong, Zhitong Jia, Xiuling Li, Xiaoyang Xu*, Xue-Qing Zhang*, ACS. Nano
• Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes
  Rady E. El-Araby, Qisheng Tu, Ying Xie, Tarek Aboushousha, Zhongyu Li,Xiaoyang Xu, Zoe X. Zhu, Lily Q. Dong, Jake Chen*, Aging and Disease

2023

• Nanoparticle-Mediated RNA Therapy Attenuates Nonalcoholic Steatohepatitis and Related Fibrosis by Targeting Activated Hepatic Stellate Cells
  Chenshuang Zhang, Yilong Teng, Fengqiao Li, William Ho, Xin Bai, Xiaoyang Xu, Xue-Qing Zhang, ACS Nano
• mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy
  Fengqiao Li, Xue-Qing Zhang, William Ho, Maoping Tang, Zhongyu Li, Lei Bu, Xiaoyang Xu, Nature Communications
• Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of KRAS-Mutant Non-Small-Cell Lung Cancer
  Guolin Zhao, William Ho, Jinxian Chu, Xiaojian Xiong, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu, Xue-Qing Zhang, ACS Appl. Mater. Interfaces
• Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 Vaccines
  Zhongyu Li, Xue-Qing Zhang, William Ho, Fengqiao Li, Mingzhu Gao, Xin Bai, Xiaoyang Xu, ACS nano

2022

• Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy.
  Wang, Bin, Maoping Tang, Ziwei Yuan, Zhongyu Li, Bin Hu, Xin Bai, Jinxian Chu, Xiaoyang Xu, and Xue-Qing Zhang, Bioactive materials 16
• Rational design of engineered H-ferritin nanoparticles with improved siRNA delivery efficacy across an in vitro model of the mouse BBB.
  Yuan, Ziwei, Bin Wang, Yilong Teng, William Ho, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu, and Xue-Qing Zhang, Nanoscale 14, no. 17
• Lipid-Polymer Hybrid
  Zhongyu Li, Xue-Qing Zhang, William Ho, Xin Bai, Dabbu Kumar Jaijyan, Fengqiao Li, Ranjeet Kumar, Afsal Kolloli, Selvakumar Subbian, Hua Zhu, Xiaoyang Xu, Particle-in-Particle" Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID-19 Vaccine". Advanced Functional Materials
• Injectable hydrogel mediated delivery of gene-engineered adipose-derived stem cells for enhanced osteoarthritis treatment Biomater.
  Xiaoyang Xu, Sci
• Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.
  Bai, Xin, Guolin Zhao, Qijing Chen, Zhongyu Li, Mingzhu Gao, William Ho, Xiaoyang Xu, and Xue-Qing Zhang, Science Advances 8, no. 25
• Injectable hydrogel mediated delivery of gene-engineered adipose-derived stem cells for enhanced osteoarthritis treatment Biomater
  Xiaoyang Xu, Sci

2021

• Next‐Generation Vaccines: Nanoparticle‐Mediated DNA and mRNA Delivery
  William Ho, Mingzhu Gao, Fengqiao Li, Zhongyu Li, Xue‐Qing Zhang*, Xiaoyang Xu*, Advanced Healthcare Materials
• Nanomedicine Approaches for Advanced Diagnosis and Treatment of Atherosclerosis and Related Ischemic Diseases
  Bin Hu, Kofi Oti Boakye-Yiadom, Wei Yu, Zi-wei Yuan, William Ho, Xiaoyang Xu*, Xue-Qing Zhang*, Adv. Healthcare Mater
• Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain
  Xue Tian, He Zhu, Shibin Du, Xue-Qing Zhang, Fuqing Lin, Fengtao Ji, Yung-Hao Tsou, Zhongyu Li, Yi Feng, Kathryn Ticehurst, Stephen Hannaford, Xiaoyang Xu, Yuan-Xiang Tao*, the Journal of Pain, 2
• An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing
  Bin Hu, Mingzhu Gao, Kofi Oti Boakye-Yiadom, William Ho, Wei Yu, Xiaoyang Xu*, Xue-Qing Zhang*, Bioactive Materials

2020

• Nanoparticle depots for controlled and sustained gene delivery
  Zhongyu Li, William Ho, Xin Bai, Fengqiao Li, Yen-jui Chen, Xue-Qing Zhang, Xiaoyang Xu, Journal of Controlled Release
• Injectable Citrate-Based Hydrogel as an Angiogenic Biomaterial Improves Cardiac Repair after Myocardial Infarction
  Zhize Yuan, Yung-Hao Tsou, Xueqing Zhang, Shixing Huang, Yang Yang, Mingzhu Gao, William Ho, Qiang Zhao, Xiaofeng Ye and Xiaoyang Xu, ACS Applied Materials & Interfaces
• Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy
  Qijing Chen, Mingzhu Gao, Zhongyu Li, Yue Xiaoa, Xin Bai, Kofi Oti Boakye-Yiadom, Xiaoyang Xu*, Xue-Qing Zhang*, J. Control. Release

2019

• Nanotechnology-Mediated Drug Delivery for the Treatment of Obesity and Its Related Comorbidities
  Yung-Hao Tsou, Bin Wang, William Ho, Bin Hu, Pei Tang, Sydney Sweet, Xue-Qing Zhang,and Xiaoyang Xu, Advanced Healthcare Materials. 2
• Lysosome-targeting NIR ratiometric luminecent upcoversion nanoprobe T toward arginine
  Zhanxian Li, Hanxiao Liu, Haixia Li, Yung-Hao Tsou, Yilin Gao, Xiaoyang Xu, Weiwei Dua, Liuhe Wei, Mingming Yu, Sensors and Actuators B: Chemical 280
• Exploring cutting-edge hydrogel technologies and their biomedical applications
  Chengde Wu, Xiaoyang Xu*, Bioactive Materials

2018

• Synthesis of PLGA/lipid hybrid nanoparticles for siRNA delivery using emulsion method
  Lei Wang, Benjamin Griffel, Xiaoyang Xu, Methods in Molecular Biology
• Dual-functional dextran-PEG hydrogel as an antimicrobial biomedical material
  Lei Wang, Xin Li, Tianyu Sun, Yung-Hao Tsou, Hong Chen, Xiaoyang Xu, Macromol. Biosci. 2
• Dopant-free hydrogels with intrinsic photoluminescent and biodegradable properties
  Yung-Hao Tsou, Xue-Qing Zhang, Yanlan Liu, He Zhu, Zhongyu Li, Jinjun Shi and Xiaoyang Xu, Advanced Functional Materials
• Bioactive Hydrogels for Bone Regeneration
  Xin Bai, Mingzhu Gao, Sahla Syed, Jerry Zhuang, Xiaoyang Xu, Xue-Qing Zhang, Bioactive Materials

2017

• Drug delivery to the brain across the blood-brain barrier using nanomaterials
  Yung-Hao Tsou, He Zhu, Sahla Syed, Xueqing Zhang and Xiaoyang Xu, Small
• Biomaterials in siRNA Delivery: A Comprehensive Review
  William Ho, Xue-Qing Zhang, and Xiaoyang Xu, Adv. Healthcare Mater

2016

• Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles with drug delivery amplification
  Yuan Xue,1 Xiaoyang Xu, 1 Xueqing Zhang, Omid C Farokhzad, Robert S Langer, Proc Natl Acad Sci USA. 2
• Nanoparticles Containing a Liver X Receptor Agonist Inhibit Inflammation and Atherosclerosis
  Zhang, X.; Even-Or, O.; Xu, X.; Rosmalen, M.; Lim, L.; Gadde, S.; Farokhzad, O.; Fisher, E. A, Adv. Healthcare Mater
• Nanomedicine: Nanotechnology, Biology and Medicine
  Xun Gao, Yung-Hao Tsou, Marina Garisb, Haidong Huang, Xiaoyang Xu, Highly specific colorimetric detection of DNA oxidation biomarker using gold nanoparticle/triplex DNA conjugate,
• Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment
  Xi Zhu, Yingjie Xu, Luisa M Solis, Wei Tao, Liangzhe Wang, Carmen Behrens, Lili Zhao, Xiaoyang Xu, Danyl Liu, Jun Wu, Ning Zhang, Ignacio I Wistuba, Omid Farokhzad, Bruce R Zetter, Jinjun shi*, Proc Natl Acad Sci USA. 2
• Hydrogel as a bioactive material to regulate stem cell fate
  Yung-Hao Tsou, Joe Khoneisser, Ping-Chun Huang, Prof. Dr. Xiaoyang Xu, Bioactive Materials. 2
• Cancer nanomedicine: from targeted delivery to combination therapy
  Xiaoyang Xu*, William Ho, Xueqing Zhang, Nicolas Bertrand, and Omid Farokhzad*, Trends in molecular Medicine. 2
• An Intestinal Trojan Horse for Gene Delivery
  Haisheng Peng, Chao Wang, Xiaoyang Xu, Chenxu Yu, and Qun Wang*, Nanoscale 2

2015

• Development of multinuclear polymeric nanoparticles as robust protein nanocarriers
  Wu, J.; Kamly, N.; Shi, J.; Zhao, L.; Xiao, Z.; Hollett, G.; John, R.; Ray. S.; Xu, X.; Zhang, X; Kantoff, P.; Farokhzad C. O, Angew. Chem. Int. Ed

2014

• Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine
  Xu, X*; Zhang, X*; Bertrand, N; Pridgen, E; Swami A; Farokhzad C. O, Adv. Drug Deliv. Rev
• Hybrid Lipid-Polymer Nanoparticles for Sustained siRNA Delivery and Gene Silencing
  Shi, J.; Xu, Y.; Xu, X.; Zhu, X.; Pridgen, E.; Votruba, A.; Zetter, B.; Farokhzad C. O, Nanomed Nanotech Biol Med 2
• Enhancing Tumor Cell Response to Chemotherapy through Nanoparticle-Mediated Co-delivery of siRNA and Cisplatin Prodrug
  Xu, X; Xie, K; Zhang, X; Pridgen, E; Park, G; Lippard, S. J.; Langer, R. S.; Walker G. C.; Farokhzad C. O, Proc Natl Acad Sci USA. 2
• Development of multinuclear polymeric nanoparticles as robust protein nanocarriers
  Wu, J.; Kamly, N.; Shi, J.; Zhao, L.; Xiao, Z.; Hollett, G.; John, R.; Ray. S.; Xu, X.; Zhang, X; Kantoff, P.; Farokhzad C. O, Angew. Chem. Int. Ed. 2
• Cancer Nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
  Bertrand, N.; Wu, J.; Xu, X.; Kamaly, N.; Farokhzad, C. O, Adv. Drug Deliv. Rev

2013

• Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine
  Xu, X*; Zhang, X*; Bertrand, N; Pridgen, E; Swami A; Farokhzad C. O, Adv. Drug Deliv. Rev

2012

• Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell–selectin interaction kinetics
  Cheng H; Byrska-Bishop M; Zhang T. C; Kastrup J. C; Hwang S. N; Tai K. A; Lee W. W; Xu X; Nahrendorf M; Langer S. R; Anderson G. D, Biomaterials; 2
• A Strategy for Increasing Drug Solubility and Efficacy through Covalent Attachment to Polycalent DNA-Nanoparticle Conjugates.
  Xu, X.; * Zhang, X.;* Lam, R.; Giljohann, D.; Ho, D.; and Mirkin C. A, ACS Nano

2011

• Polyvalent Oligonucleotide Iron Oxide Nanoparticle
  Cutler, J. I.; Zheng, D.; Xu, X.; Jiyohann D. A.; Mirkin C. A, Click" Conjugates" Nano Lett
• Multimodal Nanodiamond Drug Delivery Carriers for Selective Targeting, Imaging and Enhanced Chemotherapeutic Efficacy
  Zhang, X.; Lam, R.; Xu, X.; Kim, H.; and Ho. D, Adv. Mater. 2

2010

• Nanodiamond-Insulin Complexes as pH- Dependent Protein Delivery Vehicles.
  Shimkunas, R; Robinson, E; Lam, R; Zhang, X; Xu, X; Ho, D, Biomaterials

2009

• Sustained Transgene Expression via Citric Acid-based Polyester Elastomers
  Zhang, X; Tang, H; Hosh, I; Laporte, L. D; Qiu, H; Xu, X; Shea, L. D.; Ameer, G. A, Biomaterials
• Surprisingly Long-Range Surface Enhanced Raman Scattering (SERS) on Au-Ni Multisegmented Nanowires
  Wei, W; Li, S; Millstone, J. E; Banholzer, M; Chen, X; Xu, X; Schatz, G. C.; Mirkin, C. A, Angew. Chem. Int. Ed
• Polymer-Functionalized Nanodiamond Platforms as Vehicles for Gene Delivery.
  Zhang, X; Chen, M; Lam, R; Xu, X; Ho, D, Acs Nano
• Multimodal Gadolinium-Enriched DNA Gold Nanoparticle Conjugates for Cellular Imaging
  Xu, X.;* Song, Y.;* MacRenaris, K. W.; Zhang, X.; Mirkin, C. A.; Meade, T. J, Angew. Chem. Int. Ed
• Colorimetric Detection Cu2+ using DNA/Nanoparticle Conjugates and Click Chemistry
  Xu, X.; Deniel, W.; Wei, W.; Mirkin, C. A, Small
• A Fluorescence Recovery Assay for the Detection of Protein-DNA binding
  Xu, X.; Zhao, Z.; Qin, L.; Wei, W.; Levin, J. E.; Mirkin, C. A, Anal.Chem

2008

• Surface Plasmon-Mediated Energy Transfer in Heterogap Au−Ag Nanowires
  Wei, W., Qin, L.; Xue, C.; Millstone, J. E.; Xu, X.; Li, S.; Schatz, G. C.; Mirkin, C. A, Nano Lett
• Homogeneous Detection of Nucleic Acids Based Upon the Light Scattering Properties of Silver-coated Nanoparticle Probes
  Xu, X.; Georganopoulou, D. G.; Hill, H. D.; Mirkin, C. A, Anal. Chem
• DNA-Gold Triangular Nanoprism Conjugates
  Millstone, J. E.; Georganopoulou, D. G.; Xu, X.; Payne. E. K.; Mirkin, C. A, Small

2007

• Rational Design and Synthesis of Catalytically Driven Nano Rotors
  Qin, L.; Banholzer, M. J.; Xu, X.; Huang, L.; Mirkin, C. A, J. Am. Chem. Soc. 2
• Asymmetric Functionalization of Gold Nanoparticles with Oligonucleotides
  Xu, X.; Rosi, N. L.; Wang, Y.; Huo, F.; Mirkin, C. A, J. Am. Chem. Soc
• A Gold-Nanoparticle-Based Real-Time Colorimetric Screening Method for Endonuclease Activity and Inhibition
  Xu, X.; Han, M. S.; Mirkin, C. A, Angew. Chem. Int. Ed